BINANCE DE LA RED PI

Many proteins can self-assemble into oligomeric filaments in order to make nanoscale scaffolds or parts of a molecular machine. Changes in the protein's monomer-monomer interfaces lead to different filament morphologies, which can be essential for motor function or for different scaffolding modes. Control of this morphology is then achieved by through application of mechanical forces or modifications of the environment, through salt composition, ligand concentration, monomer concentration, etc.

How the filament responds structurally to such external stimuli can be key to understanding its function. But a challenge for studying such nanoscale objects is to combine information obtained at very different spatial and temporal scales, from the atomic to the supramolecular, and which often calls for combined efforts from researchers in both experimental and theoretical fields.

A fundamental issue that arises when trying to integrate highly diverse information from different scientific domains is forming meaningful cognitive representations that allow interpretation, reasoning, and insight.
The goal of FilaVISU is to bring together scientists working on such nanoscale systems but from distinct physical viewpoints. This workshop offers oral presentations, stimulating discussion and the possibility of interacting with one's own and others’ shared data using new integrative methodologies.